Breast cancer is the most common female cancer, with the median age at diagnosis being 62. Seventy five percent of new cases occur in postmenopausal women. Studies indicate that HRT with estrogen alone, or estrogen combined with progesterone does not increase the risk of breast cancer.
Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study
Objective: to investigate the risk factors associated with cancer and other major non-communicable diseases in women
Conclusion: No increase or decrease in breast cancer in women on E2 and progesterone
To read the complete study please click HERE
Fournier A, Berrino F, Clavel-Chapelon F. Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study [published correction appears in Breast Cancer Res Treat. 2008 Jan;107(2):307-8]. Breast Cancer Res Treat. 2008;107(1):103-111. doi:10.1007/s10549-007-9523-x
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Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality
Objective: to examine total and cause-specific cumulative mortality, including during the intervention and extended post intervention follow up, of the 2 Women's Health Initiative hormone therapy trials.
Conclusion: Hormone therapy NOT associated with increased risk of all-cause mortality, cardiovascular mortality, or cancer mortality
To read the complete study please click HERE
Manson JE, Aragaki AK, Rossouw JE, et al. Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials. JAMA. 2017;318(10):927–938. doi:10.1001/jama.2017.11217
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Hormone Replacement Therapy After a Diagnosis of Breast Cancer in Relation to Recurrence and Mortality
Objective: to evaluate the impact of HRT on recurrence and mortality after a diagnosis of breast cancer.
Conclusions:
Lower risks of recurrence and mortality in women who used HRT after a breast cancer diagnosis than in women who did not
HRT after breast cancer has NO adverse effect on recurrence or mortality
To read the complete study please click HERE
Ellen S. O'Meara, Mary Anne Rossing, Janet R. Daling, Joann G. Elmore, William E. Barlow, Noel S. Weiss, Hormone Replacement Therapy After a Diagnosis of Breast Cancer in Relation to Recurrence and Mortality, JNCI: Journal of the National Cancer Institute, Volume 93, Issue 10, 16 May 2001, Pages 754–761, https://doi.org/10.1093/jnci/93.10.754