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Writer's pictureOntario Regenerative Medicine

Testosterone, Inflammation and Chronic Pain

Testosterone plays an essential role in limiting inflammation throughout the body. Low testosterone can be the cause of joint pain. 


Effects of Testosterone on Joints and Inflammation

  • Testosterone improves most forms of chronic joint pain.

  • Testosterone improves most types of chronic muscle pain, including symptoms of osteoarthritis and fibromyalgia.

  • Testosterone can lower inflammatory markers.

  • Most autoimmune patients notice a decrease in symptoms and pain(including those with rheumatoid arthritis).


The Benefits of Testosterone for Chronic Pain Patients


  • Necessary for opioid receptor bonding.

  • Increases exercise tolerance.

  • Maintains sexual drive and function. 

  • Affects mood (decreases depression/anxiety.

  • Maintains the blood-brain barrier.

  • Maintains muscle and bone mass.

  • Prevents opioid complications, such as osteoporosis.


Bianchi VE. The Anti-Inflammatory Effects of Testosterone. J Endocr Soc. 2018;3(1):91-107. Published 2018 Oct 22. doi:10.1210/js.2018-00186

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