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Writer's pictureOntario Regenerative Medicine
Apr 10

The relationship between plasma estradiol and the increase in bone density in postmenopausal women after treatment with subcutaneous hormone implants

Objective: To investigate the factors that influence the increase in bone density with subcutaneous estradiol and testosterone implants.

  • 23 postmenopausal women

  • Received 75 mg of estradiol with 100 mg testosterone subcutaneously

  • Bone density was measured at the spine and hip, before and after 1 year of therapy



Conclusions:

  • Pellets demonstrated a much greater increase in BMD than oral estrogens or patches

  • 8.3% per year for pellets

  • 3.5% per year for patches

  • 1-2% per year for oral estrogen


To read the case study please click HERE


Garnett T, Studd J, Watson N, Savvas M, Leather A. The effects of plasma estradiol levels on increases in vertebral and femoral bone density following therapy with estradiol and estradiol with testosterone implants. Obstet Gynecol. 1992;79(6):968-972.

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