How Do Men Make Estradiol?
Aromatase is the enzyme that converts testosterone to estrogen. Estrogen receptors are abundant in the brain, penis and testis.
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Brain
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Estrogen receptors in the pre-optic area and anterior hypothalamus have high levels of aromatase and estrogen receptors which regulate libido.
Penis
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The penile vasculature and urothelium are lined with estrogen receptors. In the mature penis, estradiol modulates testosterone with the overall effect being detrimental to erectile function.
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Testis
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Leydig, Sertoli and Germ cells all produce estrogen at various stages of testes development leading to testosterone modulation. An inappropriate increase in estradiol leads to a decrease in testicular size and sperm production.
Medical Case Studies: The Impact of Estradiol on Cardiovascular Disease in Men
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