Ontario Regenerative Medicine
The Link Between Estradiol and Coronary Artery Disease (CAD)
From the Framingham Study Conclusions: Endogenous estradiol is related to CAD(Coronary Artery Disease) in men Men with severe CAD had...
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How Do Men Make Estradiol?
Aromatase is the enzyme that converts testosterone to estrogen. Estrogen receptors are abundant in the brain, penis and testis.
Brain
Estrogen receptors in the pre-optic area and anterior hypothalamus have high levels of aromatase and estrogen receptors which regulate libido.
Penis
The penile vasculature and urothelium are lined with estrogen receptors. In the mature penis, estradiol modulates testosterone with the overall effect being detrimental to erectile function.
Testis
Leydig, Sertoli and Germ cells all produce estrogen at various stages of testes development leading to testosterone modulation. An inappropriate increase in estradiol leads to a decrease in testicular size and sperm production.
Medical Case Studies: The Impact of Estradiol on Cardiovascular Disease in Men
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