Objective: To examine the relationship between serum concentration of estradiol and mortality in men with chronic HF and reduced left ventricular ejection fraction (LVEF)

Conclusion: Among men with chronic HF and reduced LVEF, high and low concentrations of estradiol compared with the middle quintile of estradiol are related to an increased mortality.

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Jankowska EA, Rozentryt P, Ponikowska B, et al. Circulating Estradiol and Mortality in Men With Systolic Chronic Heart Failure. JAMA. 2009;301(18):1892–1901. doi:10.1001/jama.2009.639