From the Framingham Study

Conclusions:

• Endogenous estradiol is related to CAD(Coronary Artery Disease) in men
• Men with severe CAD had significantly higher estradiol levels
• Men with high serum testosterone levels have lower risk of CVD (Cardiovascular Disease)

Gerald B. Phillips, William P. Castelli, Robert D. Abbott, Patricia M. McNamara, Association of hyperestrogenemia and coronary heart disease in men in the Framingham cohort, The American Journal of Medicine, Volume 74, Issue 5, 1983, Pages 863-869, ISSN 0002-9343, https://doi.org/10.1016/0002-9343(83)91078-1

Zheng H, Li Y, Dai W, Wei C, Sun K, Tong Y. Role of Endogenous Estrogen on the Incidence of Coronary Heart Disease in Men. Angiology. 2012;63(8):591-596. doi:10.1177/0003319711432626