Objective: To investigate the factors that influence the increase in bone density with subcutaneous estradiol and testosterone implants.

• 23 postmenopausal women
• Received 75 mg of estradiol with 100 mg testosterone subcutaneously
• Bone density was measured at the spine and hip, before and after 1 year of therapy

Conclusions:

• Pellets demonstrated a much greater increase in BMD than oral estrogens or patches
• 8.3% per year for pellets
• 3.5% per year for patches
• 1-2% per year for oral estrogen

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Garnett T, Studd J, Watson N, Savvas M, Leather A. The effects of plasma estradiol levels on increases in vertebral and femoral bone density following therapy with estradiol and estradiol with testosterone implants. Obstet Gynecol. 1992;79(6):968-972.