Myomar Molecular Muscle Health Assessment

Look Deeper Into Your Muscle Health

Muscle health is about more than how strong you feel—or how much muscle appears on a body-composition report.

The Myomar Muscle Health Test is a non-invasive, laboratory-analyzed urine test that measures a panel of molecular biomarkers related to muscle metabolism.

At Ontario Regenerative Medicine, Myomar results can be considered alongside your body composition, health history, physical activity, nutrition and other relevant information to provide another perspective on your muscle health.

Go beyond how much muscle you have. Learn more about what’s happening at the molecular level.

What Is the Myomar Muscle Health Test?

Myomar is a urine-based laboratory test designed to provide information about biomarkers associated with muscle metabolism.

The test involves collecting a urine sample that is analyzed by the Myomar laboratory.

Results are compiled into a personalized report that can be reviewed as part of your broader muscle-health assessment.

The test is:

• non-invasive
• urine-based
• laboratory analyzed
• designed around molecular biomarkers associated with muscle metabolism
• easy to complete without blood collection or imaging

Rather than viewing the result as a stand-alone diagnosis, ORM uses the information as one piece of a more complete muscle-health picture.

Why Measure Muscle Biomarkers?

Muscle Health Can’t Always Be Described by One Measurement

Different assessments tell us different things.

A body-composition assessment can estimate how much skeletal muscle you have and how lean mass is distributed throughout your body.

Functional assessment can provide information about how you move or perform.

Molecular biomarker testing provides a different type of information.

Myomar analyzes urine biomarkers associated with biological processes involving muscle metabolism.

These approaches don’t necessarily replace one another.

They can provide different pieces of information about muscle health.

What Does Myomar Measure?

The Myomar laboratory analyzes a proprietary panel of biomarkers associated with muscle metabolism.

According to Myomar, the panel includes biomarkers relating to areas such as:

• amino-acid metabolism
• muscle protein turnover
• byproducts associated with myofibrillar protein breakdown
• other metabolic processes relevant to skeletal muscle

The laboratory combines its biomarker measurements and analytical methodology to generate the patient’s Myomar Muscle Health Report.

Because the test uses a proprietary biomarker panel and algorithm, individual results should be interpreted according to the laboratory’s validated methodology and within the context of the individual patient.

Muscle Protein Turnover

Muscle Is Constantly Changing

Skeletal muscle isn’t static tissue.

Proteins within muscle are continuously being synthesized and broken down as part of normal physiology.

This ongoing process is referred to as muscle protein turnover.

Factors such as:

• age
• physical activity
• exercise
• nutrition
• health
• periods of inactivity
• other physiological factors

can influence muscle biology.

Myomar measures molecular biomarkers associated with these processes to provide additional information for consideration within a muscle-health assessment.

Molecular Information vs. Body Composition

They Answer Different Questions

At ORM, we don’t believe one measurement tells the entire story.

InBody Body Composition Analysis

InBody can provide estimates of measurements such as:

• skeletal muscle mass
• segmental lean mass
• body fat
• fat-free mass
• body water

This helps answer:

“What does my body composition look like today?”

Myomar Molecular Testing

Myomar analyzes molecular biomarkers associated with muscle metabolism.

This provides a different type of information:

“What do these muscle-related molecular biomarkers show?”

The two assessments can therefore provide complementary information when clinically appropriate.

Why Might Someone Want a Myomar Assessment?

You may be interested in learning more about your muscle health if:

• you’ve noticed changes in strength or physical performance
• you’re interested in maintaining muscle as you age
• you’re tracking changes in your body composition
• you’re beginning or modifying a fitness program
• you’re working on nutrition and muscle-health goals
• you’ve experienced a period of reduced physical activity
• you’re interested in establishing a baseline
• you want information beyond body weight alone
• you want to track muscle-related measurements over time

These circumstances don’t establish that something is wrong with your muscle.

They may simply be reasons to understand it better.

Myomar & Healthy Aging

Muscle Deserves Attention Throughout Adulthood

Changes in skeletal muscle can become increasingly relevant as we age.

Maintaining physical capacity involves more than simply watching body weight.

Understanding muscle mass, strength, function and other relevant measurements can provide useful information when considering long-term physical health.

Molecular biomarker information may add another perspective when it is appropriate for the individual.

The objective isn’t to find a problem.

It’s to better understand where you are today.

How Does the Myomar Test Work?

Step 1 — Receive Your Myomar Kit

ORM provides your Myomar collection kit along with instructions for completing the test.

The kit contains the materials required to collect your urine sample.

Step 2 — Collect Your Sample

You’ll collect your urine sample according to the instructions provided with the kit.

Because the test is urine-based, no blood draw is required.

Step 3 — Complete the Questionnaire

You’ll also complete a digital questionnaire.

This provides additional information that can help place your laboratory results in context.

Step 4 — Return Your Sample

Your sample is returned to the Myomar laboratory using the provided materials and instructions.

Step 5 — Laboratory Analysis

The laboratory analyzes its proprietary panel of muscle-related molecular biomarkers.

The results are processed according to Myomar’s analytical methodology to generate your report.

Step 6 — Receive Your Muscle Health Report

Your results are compiled into a personalized Myomar Muscle Health Report.

Rather than simply looking at a score in isolation, the report can be reviewed within the broader context of your muscle health.

Step 7 — Review Your Results With ORM

You can meet with the ORM team to discuss your report and what the findings may mean in the context of:

• your body composition
• physical activity
• nutrition
• health history
• medications
• hormone health when relevant
• other appropriate clinical information

If additional assessment is appropriate, your provider can discuss the next steps with you.

Your Myomar Score

The Myomar report may include a proprietary score derived from the laboratory’s biomarker analysis.

A score can make complex information easier to understand, but it shouldn’t be interpreted as a complete assessment of your muscle health by itself.

Your result should be considered alongside the underlying biomarker information and your broader clinical context.

One score isn’t the whole story.

Can Myomar Detect Muscle Loss Before I Notice It?

Molecular biomarker testing is intended to provide information about biological processes that may not be apparent from body weight or appearance alone.

However, a Myomar result should not be treated as a stand-alone diagnosis of muscle loss, sarcopenia or another medical condition.

If your results raise a concern, additional assessment may be appropriate.

Can Myomar Tell Me Why My Muscle Has Changed?

Not necessarily.

A laboratory test can provide information about the biomarkers it measures, but changes in muscle mass, strength or function can have many possible contributing factors.

These may include:

• physical activity
• nutrition
• aging
• illness or injury
• medications
• hormonal factors
• periods of inactivity
• other individual circumstances

Your healthcare provider can consider the Myomar findings together with other information when determining whether further investigation is appropriate.

Can Myomar Measure My Muscle Mass?

Myomar is a molecular urine test.

It should not be confused with a direct measurement or body-composition estimate of skeletal muscle mass.

At ORM, body-composition analysis can provide additional information about estimated skeletal muscle mass and lean-mass distribution.

That’s one reason the two approaches can be useful together.

Can Myomar Tell Me How Strong I Am?

No.

Muscle biomarkers, muscle mass and muscle strength are different measurements.

A molecular urine test does not replace appropriate assessment of physical strength or function when those measurements are relevant.

Tracking Muscle Health Over Time

Look for Meaningful Trends

Depending on your individual goals and circumstances, repeat assessment may be considered.

Tracking results over time may provide information about changes in the measurements being evaluated.

However, changes should be interpreted carefully.

A change in a biomarker or score doesn’t automatically establish that a particular exercise program, diet, supplement or medical treatment caused the change.

Your provider can help place repeat results into context.

Myomar + InBody

Two Different Views of Muscle Health

ORM can combine different forms of assessment when appropriate.

InBody

Helps estimate how much muscle you have and how it is distributed.

Myomar

Provides molecular biomarker information associated with muscle metabolism.

Your Health Assessment

Provides the context needed to understand why the information may matter.

Together, these can provide a broader view than relying on body weight alone.

A More Complete Muscle Health Assessment

ORM’s approach may consider several dimensions of muscle health:

Body Composition

How much estimated skeletal muscle and body fat contribute to your body composition?

Muscle Distribution

How is estimated lean mass distributed throughout your body?

Molecular Biomarkers

What information does your Myomar report provide about the biomarkers it measures?

Strength & Function

Have you noticed changes in your physical capacity or everyday activities?

Nutrition & Activity

What factors may be relevant to maintaining your muscle?

Medical Context

Are there health, medication, hormonal or other considerations that warrant further assessment?

The objective is not simply to produce more numbers.

It’s to make the numbers more meaningful.